Romancing the fly

Nature Neuroscience pp 54 – 61

Male Drosophila that lack a transport protein specific to glial cells do not distinguish females from males in their courtship behaviour, reports a paper in the January issue of Nature Neuroscience. These results suggest that glial cells — non neuronal cells that provide support for neurons — have an important function in the brain circuitry that underlies mate recognition.

During courtship, male flies typically serenade females. David Featherstone and colleagues find that when the gene for a glial glutamate transporter was inactivated, the males serenaded other males just as enthusiastically. The mutant males did not respond appropriately to male-specific pheromones, being attracted to one male pheromone that normally suppresses male courtship behaviour.

The importance of glial cells in brain function is often underestimated. This particular glial transporter, which the authors named 'genderblind', is responsible for maintaining correct levels of the neurotransmitter glutamate in the extracellular space. Changes in glutamate would be expected to affect the function of the nerve cells that govern mate recognition, though the exact details of this circuitry remain to be figured out.

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